Abstract One objective of Artemis science is to determine the impact human activities have on the lunar environment, which might compromise science objectives and measurements. We perform a preliminary analysis of the contamination associated with airlock venting and outgassing from a prototype lunar module geometry intended to host astronauts on the lunar surface. The air flow generated by the depressurization of the airlock, expanding in the lunar exosphere, is studied using the Direct Simulation Monte Carlo method for two different venting configurations and the particle flux on the surface is computed as a function of the distance from the module. Outgassing from the main body of the module—assumed to be covered with multilayer insulation blanketing—and from the solar panels is then analyzed using a view-factor method, employing outgassing rates from the literature. Our results give preliminary indications of the distance at which contamination levels fall below the values characteristic of native species in the lunar atmosphere. Scientific measurements targeting 40 Ar should be carried out farther than 30–100 m from the module, while the detection of lower-abundance species such as polar crater water might require traveling up to and beyond 3 km from the module.