Abstract Visible-to-shortwave infrared (VSWIR) reflectance spectroscopy has revolutionized our understanding of planetary surface compositions. However, space-weathering processes on airless bodies complicate quantitative compositional analyses. Here, we present a framework to isolate the signatures of space weathering in VSWIR spectra of lunar maria by leveraging radiative transfer modeling under the assumptions that (i) a space-weathered target can be expressed as a mixture of fresh and fully space-weathered components and (ii) remaining signatures can be modeled by including agglutinates as an end-member component. We first validate this approach against laboratory spectra of space-weathered Apollo mare soils of known mineral compositions using a probabilistic Markov Chain Monte Carlo implementation of the Hapke radiative transfer model. Second, we illustrate how this approach can be applied to orbital Moon Mineralogy Mapper data. The proposed space-weathering correction workflow for lunar maria could be expanded to other lunar lithologies and applied to existing and future data sets.