Abstract We present observations of two binary systems within the cold classical region of the Kuiper Belt—2001 XR254 and 2016 BP81—obtained with the JWST Near-Infrared Spectrograph. The measured reflectance spectrum of 2001 XR254 is characteristic of the red cold classicals, with strong features due to carbon dioxide, carbon monoxide, and methanol ices. In contrast, 2016 BP81 is a blue binary, with a spectrum that shows prominent water-ice absorption bands. The two components of the 2016 BP81 binary display identical spectral profiles, consistent with coeval formation from gravitational collapse. Through qualitative and quantitative comparisons of Kuiper Belt objects (KBOs) with similar spectral profiles dominated by water-ice features, we identify a small cluster, including 2016 BP81, that differs in systematic ways from the rest of the population. The relatively deep carbon dioxide ice absorption bands, different water-ice band-depth ratios, and possibly enhanced signatures of aliphatic organics suggest that objects in this cluster may have originated in a distinct formation environment from the other water-type KBOs. The implications of our findings are discussed within the context of recent models of Kuiper Belt formation and evolution.