Abstract Accurately characterizing the intrinsic stellar photometric noise induced by stellar astrophysics, such as stellar activity, granulation, and oscillations, is of crucial importance for detecting transiting exoplanets. In this study, we investigate the relation between the intrinsic stellar photometric noise, quantified by the Kepler combined differential photometric precision (CDPP) metric, and the level of stellar chromospheric activity, indicated by the S-index of Ca ii H K lines derived from LAMOST spectra. Our results reveal a clear positive correlation between the S-index and robust rms values of CDPP, with the correlation becoming more significant at higher activity levels and on longer timescales. We have therefore built an empirical relation between the robust rms values of CDPP and the S-index as well as T eff, log g, [Fe/H], and the apparent magnitude, with the XGBoost regression algorithm, using the LAMOST–Kepler common star sample as the training set. This method achieves a precision of ∼20 ppm for inferring the intrinsic noise from the S-index and other stellar labels on a 6 hr integration duration. We have applied this empirical relation to the full LAMOST DR7 spectra database and obtained the intrinsic noise predictions for 1,358,275 stars. The resultant catalog is publicly available and expected to be valuable for optimizing target selection for future exoplanet-hunting space missions, such as the Earth 2.0 mission.