This paper examines the LTE mobile communication base stations possible interfering effects on short range communication devices operating in ISM frequency band. LTE network is running in 2500–2690 MHz frequency band, where frequency channel distribution is used. Downlink channels are assigned to base stations and formed in 2620–2680 MHz band, uplink channels are assigned to mobile stations and formed in 2500–2560 MHz band. Short range communication devices operate in 2400–2483.5 MHz frequency range. The main problem of this study – the interference probability and magnitude. Real equipment was simulated using two different modelling software systems for investigation of electromagnetic compatibility: ICS Telecom and Seamcat. The modelling results show that LTE BS have minimum or no impact on operation of short range communication devices in ISM frequency band.