The high level of reported multidrug resistant pathogens with the failure of most conventional antibiotic to kill many of them arise the global concern in the last decade to find alternatives urgently. Many researches are conducted on scorpion venom area and different antimicrobial peptides had been reported in literature also  many had been functionally characterized in the last decade. Here quick overview of all scorpion AMPs with antibacterial activity , their Structural determinants, classification types and their mode of action, in addition to their resistance mechanism and finally their therapeutics potential