DEET remains one of the most effective repellents against a wide variety of insects. Although adverse reactions have been reported in the medical literature and magnified in the press, the compound is remarkably safe and has been used by hundreds of millions of people over the past 40 years. Permethrin is a better deterrent of ticks and, like DEET, is remarkably safe. Concomitant use of these two agents provides superior protection. Citronella and a bath oil, Avon Skin-So-Soft, also provide limited protection against some types of flying insects. The promise of new agents or protective strategies is on the horizon. Recently it was shown that retroviral vectors could be used to integrate and express foreign genes in the malaria mosquito, Anopheles gambiae. Conceivably, a genetically engineered mosquito that is resistant to malaria and other transmissible diseases may one day be developed, obviating some of the need for repellents. Almost certainly, future research will yield additional agents to further protect against mosquitoes.