In order to produce significant muscle hypertrophy, a training intensity of greater than 65% of the 1-repetition maximum (1-RM) is generally believed to be required. However, this concept has been challenged recently by data from studies that have combined 20%-50% 1-RM with restriction of venous blood flow from the working muscle, referred to as KAATSU-training. These studies have demonstrated significant gains in muscle size and strength in as little as 2 weeks in humans. The KAATSU-training model may have utility in models other than humans; several recent papers have investigated the safety and potential utility of KAATSU-training in an equine model. The purpose of this brief review is to discuss the horse as a viable model of KAATSU-training and discuss the available data using this model thus far.