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Transcranial Direct Current Stimulation (tDCS) in Mice

descriptionPublicationkeyboard_double_arrow_right Article 23 Sep 2018 English Publisher:MyJove CorporationJournal:Journal of Visualized Experiments (eissn: 1940-087X,

Authors: Eduardo de Souza Nicolau; Nycolle Ferreira Nicolau; Mélcar Collodetti; Débora Marques de Miranda; Helia Tenza-Ferrer; Luiz Alexandre V. Magno; Kevin Augusto Farias de Alvarenga; +3 Authors

doi: 10.3791/58517-v , 10.3791/58517

pmid: 30295664

pmc: PMC6235291

Transcranial Direct Current Stimulation (tDCS) in Mice

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Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique proposed as an alternative or complementary treatment for several neuropsychiatric diseases. The biological effects of tDCS are not fully understood, which is in part explained due to the difficulty in obtaining human brain tissue. This protocol describes a tDCS mouse model that uses a chronically implanted electrode allowing the study of the long-lasting biological effects of tDCS. In this experimental model, tDCS changes the cortical gene expression and offers a prominent contribution to the understanding of the rationale for its therapeutic use.

Related Organizations

Universidade Federal de Minas Gerais
Brazil
Universidade Federal de Minas Gerais
Brazil

Keywords

Mice, Animals, Brain, Humans, Transcranial Direct Current Stimulation, Electrodes, Implanted

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