ABSTRACT Objectives: The objective of this study is to compare the outcome of mini cholecystectomy with open conventional cholecystectomy in the management of cholelithiasis. Study Design: This was a randomized controlled trial. Study Period: Study was conducted in Department Of Surgery, Teaching Hospital Dera Ghazi Khan, from June 2017 to Dec 2017 for a period of six month. Patients and Methods: A total of 100 cases; 50 cases in each group was included in the study. 100 patients were admitted from OPD of Teaching Hospital Dera Ghazi Khan fulfilling inclusion criteria. Demographic information was recorded. All admitted patients were diagnosed on the basis of history, clinical examination and relevant investigations. Written consent was obtained. Data entry and analysis was done by using SPSS 11. Data was analyzed according to the proposed analysis plan. Results: Mean age of all patients was 39.96±3.84 years. Age range of patients was 30-48 years. In Group-A mean hospital stay was 5.38±1.15 and in Group-B mean hospital stay was 3.02±0.58 days respectively. At 1st visit 14(28%) patients in Group-B and only 1(2%) patient in Group-A had wound infection. According to p-value wound infection was significantly associated with treatment group. Patients in Group-A had less infection rate as compared to Group-B patients. i.e. (p-value=0.000) Whereas at 2nd visit 8(16%) patients in Group-B and 3 patients in Group-A suffered from wound infection. At 2nd visit wound infection was statistically same in both treatment groups. i.e. (p-value=0.110). It was observed that in Group-B only 44(88%) of the patients had severe pain whereas only 12(24%) of the patients in Group-A had severe pain. Keeping in mind this results rate of severe pain at 12th hour was high in Group-B patients as compared to Group-A patients. i.e. (p-value=0.000). Conclusion: Mini cholecystectomy is effective and associated with less patients discomfort in terms of post operative pain and infection as well as with less hospital stay.