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Functional and Anatomical Correlates of Impaired Velocity Storage

Authors: Gary P, Jacobson; Devin L, McCaslin; Suresh, Patel; Kamrin, Barin; Nabih M, Ramadan;

Functional and Anatomical Correlates of Impaired Velocity Storage

Abstract

Velocity storage (VS), a brainstem function, extends the low-frequency response of the vestibular system. To better understand VS mechanisms and characteristics in humans, we analyzed retrospectively functional measures of gait, electrophysiological measures of vestibular function, and imaging studies in an attempt to determine clinical, electrophysiological, and anatomical correlates of abnormalities in VS.Two cohorts of patients referred to our Risk of Falls Assessment Clinic participated in this investigation. Group 1 (control) patients demonstrated normal caloric and rotary chair tests. Group 2 patients with impaired velocity storage (experimentals) differed clinically from Group 1 only by demonstrating abnormal multifrequency vestibulocular reflex phase measures on rotational testing.Results showed that Group 2 patients had greater impairments in postural stability and gait than Group 1 patients. Additionally, 80% of patients in Group 2 and none in Group 1 showed pontine hyperintense lesions on MRI. La velocidad de almacenamiento (VS), una función del tallo cerebral, Amplía la respuesta a bajas frecuencias del sistema vestibular. Para entender mejor los mecanismos y características de la VS en humanos, analizamos retrospectivamente medidas funcionales de la marcha, medidas electrofisiológicas de función vestibular, y estudios de imágenes, en un intento de determinar correlaciones clínicas, electrofisiológicas y anatómicas en las anormalidades de la VS.Dos cohortes de pacientes referidos a nuestra Clínica de Evaluación de Riesgo de Caídas participaron en esta investigación. Los pacientes del Grupo 1 (control) demostraron normalidad en las pruebas calóricas y de silla rotatoria. Los pacientes del Grupo 2 con velocidad de almacenamiento alterada (experimentales) fueron diferentes de aquellos del Grupo 1 sólo por demostrar medidas anormales en la fase de reflejo vestíbulo-ocular multifrecuencial, en pruebas de rotación.Los resultados mostraron que los pacientes del Grupo 2 tenían mayor alteración en la estabilidad postural y la marcha, que los pacientes del Grupo 1. Además, el 80% de los pacientes en el Grupo 2 y ninguno del Grupo 1, mostraron lesiones pontinas hiperintensas en la RMN

Related Organizations
Keywords

Aged, 80 and over, Male, Electronystagmography, Reflex, Vestibulo-Ocular, Middle Aged, Vestibular Function Tests, Dizziness, Magnetic Resonance Imaging, Brain Ischemia, Cohort Studies, Vestibular Diseases, Case-Control Studies, Humans, Female, Vestibule, Labyrinth, Gait, Postural Balance, Aged, Brain Stem, Retrospective Studies

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
10
Average
Average
Average
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