The extent to which motor impairment generalizes following a 1.5-g/kg IP dose of alcohol was investigated in two lines of rats bred to be either “most” (MA) or “least” (LA) affected by alcohol. Motor impairment was assessed on several measures of general activity at approximately 60–65 days of age. MA rats were found to be significantly more impaired than LA rats in the stabilimeter and open field following alcohol, although no differences were present following saline injection. In the running wheel, activity was lower for MA as compared to LA animals following saline, although the two lines were still differentially affected by alcohol. These findings are thought to demonstrate that the disparate responses to alcohol are not unique to stabilimeter activity upon which the two lines were selectively bred, but instead indicate generalized differences in alcohol sensitivity. The utility of these lines for studying differential sensitivity to alcohol among individuals is discussed.