The influence of an isolated word’s meaning on lexical decision reaction time (RT) was demonstrated through four experiments. Subjects in two experiments made lexical decision judgments, those in a third experiment pronounced the words used in the lexical decision task, and those in a fourth experiment quickly pronounced their first associative response to the words. Differences in lexical access time for the words were measured with the pronunciation task, and differences in meaning were assessed with the association task. Multiple regression analyses of lexical decision RT were conducted using associative RT, pronunciation RT, and other target word properties (printed frequency, length, instance dominance, and number of dictionary meanings) as predictor variables. These analyses revealed a relationship between lexical decision RT and associative RT after the effects of other variables had been partialed out. In addition, word frequency continued to have a significant relationship to lexical decision RT beyond that shared with pronunciation RT and the other variables. The results of these experiments indicate that at least some of the effect of word meaning and word frequency in lexical decision is attributable to a decision stage following lexical access.