Recent studies have shown that spatial Simon effects can be modulated by short-term associations that are set up as a result of task instructions. I examined whether spatial Simon effects can also be produced by short-term associations even when the responses are unrelated to spatial position. Participants were to say "cale" or "cole" on the basis of the direction of arrows (i.e., left or right), the meaning of words (i.e., left or right), and the color of squares presented left or right of the screen center. Responses to squares were faster when the correct response was associated with the same position as the irrelevant position of the square (e.g., say "cale" to a square on the left when "cale" was assigned to the word left and the left arrow). This new type of stimulus-response compatibility effect provides the first evidence for short-term associations that involve mode-independent representations.