
The pathogenesis of intrahepatic cholestasis of pregnancy (ICP), a disorder that adversely affects maternal wellbeing and fetal outcome, is unclear. However, multiple factors probably interact along with a genetic predisposition. We would like to add some comments on a paper recently published concerning the role of ABCB11 and ABCC2 polymorphisms in both ICP and contraceptive-induced cholestasis, especially in the light of our recently published findings about a positive association between ICP and ABCC2 common variants.
Heterozygote, ABCC2, Cholestasis, Intrahepatic, Gene variants, Pregnancy, Intrahepatic cholestasis of pregnancy, https://purl.org/becyt/ford/1.6, https://purl.org/becyt/ford/3.2, Contraceptive Agents, Female, Humans, Genetic Predisposition to Disease, https://purl.org/becyt/ford/3, https://purl.org/becyt/ford/1, ATP Binding Cassette Transporter, Subfamily B, Member 11, Polymorphism, Genetic, MRP2, Genetic Variation, Membrane Transport Proteins, Multidrug Resistance-Associated Protein 2, Pregnancy Complications, ATP-Binding Cassette Transporters, Female, Multidrug Resistance-Associated Proteins
Heterozygote, ABCC2, Cholestasis, Intrahepatic, Gene variants, Pregnancy, Intrahepatic cholestasis of pregnancy, https://purl.org/becyt/ford/1.6, https://purl.org/becyt/ford/3.2, Contraceptive Agents, Female, Humans, Genetic Predisposition to Disease, https://purl.org/becyt/ford/3, https://purl.org/becyt/ford/1, ATP Binding Cassette Transporter, Subfamily B, Member 11, Polymorphism, Genetic, MRP2, Genetic Variation, Membrane Transport Proteins, Multidrug Resistance-Associated Protein 2, Pregnancy Complications, ATP-Binding Cassette Transporters, Female, Multidrug Resistance-Associated Proteins
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