Stress is a global menace exacerbated by the advancement of industrialization. Failure of stress management is to a breakdown of the psychological and physiological protection mechanisms against stress. The aim of present study was to investigate the anti-stress potential of ginseng against immobilization stress. Male Sprague-Dawley rats (n=24) were divided into three groups; (ⅰ) control, (ⅱ) immobilization stress (2 hr daily, for 2 weeks), and (ⅲ) immobilization stress (2 hr daily, for 2 weeks) plus oral administration of ginseng (200 mg/kg BW/d). Immobilization stress resulted in a significant inhibition of body weight gain by 45% and a significant decrease in the tissue weights of thymus and spleen (p＜0.05). The concentrations of blood GOT and GPT were significantly increased in the immobilization-stressed group compared to the control group (p＜0.05). There were no differences in the blood cholesterol levels among groups. Ginseng administration in the immobilization-stressed group tended to reverse the lack of body weight gain and food intake, though not significantly. The ginseng-administered group showed a significant reversal in the stress-induced effect on spleen and thymus weight, increasing the tissue weights by 16% and 20%, respectively, compared to immobilization-stressed group (p＜0.05). The plasma corticosterone level was significantly increased in the stressed group by 39% compared to the control group (p＜0.05), but ginseng administration significantly reversed the stress-induced increase in plasma corticosterone by 15% compared to the immobilization-stressed group. The present study suggests that the anti-stress effect of ginseng is mediated by normalization of stress-induced changes in the circulating hormones and a reversal of tissue weight loss, thereby returning the body to normal homeostasis.