Herbal plants have been used by a majority of people due to its pharmacological properties. Recently, herbal medicinal is got more attention by scientist due to appearance of antibiotic resistant bacteria. Ginger is a one of medicinal plant which used around the world as flavoring agent in food in both fresh and dried forms. Also, ginger has multiple therapeutic action such as anti-tumorigenic, anti-apoptotic, anti-oxidant activities which attributed to its active polyphenol compounds as gingerols and shogaols. Recently, ginger nanoparticles have been isolated from ginger extract and involved in drug delivery system without induction of side effects. This review paper briefly summarizes the pharmacological characterization and different therapeutic applications of ginger in both extract and nano-size form.