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Jurnal Farmasi (Journal of Pharmacy)
Article . 2019 . Peer-reviewed
License: CC BY
Data sources: Crossref
image/svg+xml art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos Open Access logo, converted into svg, designed by PLoS. This version with transparent background. http://commons.wikimedia.org/wiki/File:Open_Access_logo_PLoS_white.svg art designer at PLoS, modified by Wikipedia users Nina, Beao, JakobVoss, and AnonMoos http://www.plos.org/
Jurnal Farmasi (Journal of Pharmacy)
Article
License: CC BY
Data sources: UnpayWall
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Optimasi Kapsul Bawang Putih (Allium sativum Linn) sebagai Terapi Alternatif Pengobatan TBC

Authors: Novena Yety Lindawati; Hartono Hartono;

Optimasi Kapsul Bawang Putih (Allium sativum Linn) sebagai Terapi Alternatif Pengobatan TBC

Abstract

Bawang putih (Allium sativum Linn) terbukti aktif terhadap Mycobacterium tuberculosis. Senyawa alisin yang terkandung dalam bawang putih (Allium sativum Linn) berfungsi sebagai antimikroba spektrum luas yang mampu menghambat bakteri penyebab TBC. Kapsul bawang putih (Allium sativum Linn) harus memenuhi persyaratan sesuai dengan Keputusan Menteri Kesehatan Republik Indonesia No: 661/MENKES/SK/VII/1994 tentang persyaratan obat tradisional. Hasil penelitian menunjukkan ekstrak bawang putih memiliki khasiat sama dengan bawang puting lanang, pada dosis 240 µg/ml medium (setara dengan 600 mg ekstrak bawang putih per kapsul) memiliki potensi paling besar dalam menghambat pertumbuhan Mycobacterium tuberculosis (diambil dari koloni biakan murni dari kultur sputum pasien yang menderita TBC jenis BTA +2, kultur positif 9, resisten terhadap rifampisin) dibanding dosis 320 dan 400 µg/ml media. Ekstrak kering bawang putih (Allium sativum Linn) memenuhi persyaratan sebagai bahan isi kapsul obat tradisional, antara lain angka lempeng total 1.5 (dipersyaratkan tidak lebih dari 10); angka kapang dan khamir ekstrak bawang putih 6.102 (dipersyaratkan tidak lebih dari 104); tidak mengandung mikroba patogen (tidak terkontaminasi bakteri coliform, Eschericia coli, Salmonella sp, dan Staphylococcus aureus); tidak terdeteksi adanya aflatoxin (dipersyaratkan tidak lebih dari 30 bpj); kadar air rata-rata sebesar 1 sampai 2 % (dipersyaratkan tidak lebih dari 10 %). Kapsul ekstrak kering bawang putih (Allium sativum Linn) memenuhi persyaratan farmasetika untuk sediaan kapsul obat tradisional hasil uji waktu hancur kurang lebih 13 menit (dipersyaratkan tidak lebih dari 15 menit) dan memenuhi keseragaman bobot yang dipersyaratkan untuk sediaan kapsul.

  • BIP!
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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
hybrid