Benign Familial Pemphigus (Hailey-Hailey Disease [HHD]) is a rare chronic condition, with treatments focusing on managing disease symptoms.We present a case of a 72-year-old female with refractory HHD. Despite management with standard HHD treatments, such as antibiotics and corticosteroids, the patient's flares persisted. She was started on ruxolitinib 1.5% cream, with improved symptoms.This case demonstrates the difficulties a patient with refractory HHD may experience, and the significance of exploring novel treatment options to improve disease response and patient quality of life.Ruxolitinib may be an effective treatment option for HHD management, but further investigation is necessary.