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Hepatitis C virus (Flaviviridae: Hepacivirus: Hepacivirus C): regulation of signaling reactions of innate immunity

Name: Hepatitis C virus (Flaviviridae: Hepacivirus: Hepacivirus C): regulation of signaling reactions of innate immunity
Creator: T. M. Sokolova
Keywords: 0301 basic medicine, 0303 health sciences, Toll-Like Receptors, Hepacivirus, hepatitis c virus, Virus Replication, Microbiology, Hepatitis C, QR1-502, Immunity, Innate

descriptionPublicationkeyboard_double_arrow_right Article 07 Jan 2021Publisher:Central Research Institute for EpidemiologyJournal:Problems of Virology, volume 65, pages 307-316 (issn: 0507-4088, eissn: 2411-2097,

Authors: T. M. Sokolova;

doi: 10.36233/0507-4088-2020-65-6-1

pmid: 33533227

Hepatitis C virus (Flaviviridae: Hepacivirus: Hepacivirus C): regulation of signaling reactions of innate immunity

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Abstract

Studying the regulation of signaling reactions of innate immunity by the hepatitis C virus (HCV) will help to reveal the causes of the transition of the acute form of the disease to a chronic course. The molecular mechanisms of activation by HCV RNA of innate immunity receptors TLR and RLR and signal transduction processes leading to the synthesis of IFN and inflammatory cytokines are considered. The inhibitory effects of non-structural and structural HCV proteins on immune signaling reactions are analyzed in detail. The information presented is the result of an analysis of literature data published in international databases mainly over the past 5 years. In conclusion, signaling receptors are proposed as targets for the development of new antiviral drugs with immunotherapeutic activity.

Keywords

Toll-Like Receptors, Hepacivirus, hepatitis c virus, Virus Replication, Microbiology, Hepatitis C, QR1-502, Immunity, Innate, Host-Pathogen Interactions, Cytokines, Humans, RNA, Viral, signaling reactions of tlr and rlr receptors, production of ifn and inflammatory cytokines, Interferons, innate immunity, Signal Transduction

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