Humeral shaft fractures represent approximately 3% of all long-bone fractures and have historically been treated successfully in a non-operative way, but surgical management is indicated in several conditions. Although there are numerous randomized clinical trials and meta-analyses that have attempted to guide surgeons, there is little evidence and no consensus as to the most suitable treatment. Every treatment has its advantages and its complications, and many factors must be considered: not only the features of the fracture, but also patient compliance and surgeon experience.