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Global Health & Medicine

Article . 2024 . Peer-reviewed

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Global Health & Medicine

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HIV-1 protease inhibitors and mechanisms of HIV-1's resistance

Name: HIV-1 protease inhibitors and mechanisms of HIV-1's resistance
Creator: Debananda, Das

descriptionPublicationkeyboard_double_arrow_right Article 27 Dec 2024 English Publisher:National Center for Global Health and Medicine (JST)Journal:Global Health & Medicine, volume 6, pages 357-362 (issn: 2434-9186, eissn: 2434-9194,

Authors: Debananda, Das;

doi: 10.35772/ghm.2024.01073

pmid: 39741988

pmc: PMC11680448

HIV-1 protease inhibitors and mechanisms of HIV-1's resistance

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Abstract

Current anti-HIV drugs have significantly improved the prognosis of HIV infected patients so much so that it is now considered a chronic disease, and adherence to medications keeps non-detectable amounts of the virus in the body. However, HIV is still able to generate drug resistance substitutions. Protease inhibitors (PIs) in combination with other classes of anti-HIV drugs constitute an important part of the anti-HIV drug regimen. This article discusses some of the common resistance substitutions against PIs, mechanistic insight on resistance, and potential new inhibitors that can show efficacy against current resistant variants.

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