RESEARCH OBJECTIVE: The research aims to explore the evolution and multifactorial determinants of international biopolitics, emphasizing how global governance shapes biological life across borders. THE RESEARCH PROBLEMS AND METHODS: The study investigates international biopolitics as governance increasingly transitions from national to supranational entities, impacting health, population management, and biological well-being. It employs a mixed-methods approach, integrating systematic literature reviews, comparative policy analyses, and quantitative statistical modelling, including indices measuring biopolitical intensity and technological capabilities. THE PROCESS OF ARGUMENTATION: Initially, the article contextualizes biopolitics historically through Foucauldian theory, advancing towards a contemporary understanding shaped by globalization and international collaboration. The argument introduces a novel conceptual framework termed „Mutating Colourful Swans,” categorizing disruptive global phenomena – environmental crises (Green), conflicts (Red), migrations (Yellow), and technological advancements (Blue) – to systematically analyse their biopolitical impacts. RESEARCH RESULTS: Empirical findings suggest technologically advanced nations demonstrate more intensive biopolitical practices, with technology accounting for approximately 60% of cross-national variation. Further regression analyses reveal international biopolitical governance is collectively influenced by economic, socio-demographic, political, technological, and environmental determinants, though no single factor is dominant. CONCLUSIONS, INNOVATION, AND RECOMMENDATIONS: The study concludes international biopolitics emerges from the synergistic interaction of multiple determinants, highlighting the need for adaptable governance frameworks. The innovative „Mutating Colourful Swans” model serves as a practical analytical tool for anticipating and managing future biopolitical disruptions. The authors recommend interdisciplinary collaboration, enhancement of real-time biosurveillance networks, improvement of biopolitical quantitative metrics, and employment of scenario-based foresight methods to strengthen global governance responses to emerging biopolitical challenges.