There is no doubt that Brexit is an unprecedented event in the history of European integration and the European Union (EU). It will certainly be a turning point not only in the history of the EU but also in Germany and France. It will affect their place and role in the new international order that is currently being shaped. Today, however, it is very difficult to present an accurate diagnosis, and even more difficult to predict the future of the EU, Europe and the whole world after Brexit. Currently, the opinions of researchers and experts on this subject are divided. Many fear that Brexit will be the beginning of the end of the EU and that it will lead to so-called diversified integration and then to its disintegration. Others believe that Brexit, nolens volens, may accelerate the EU’s modernisation process. This will require the adoption of a new revision treaty. This treaty will be developed under the dictation of Germany and France, which are the most influential countries in the EU.The purpose of this article is to answer a few questions, particularly what role Germany and France can and will play in the EU after Brexit. Will these countries again become the driving force in the process of European integration and the EU’s modernisation, or will they remain passive and contribute to the break-up of the EU? Moreover, the author intends to show the opportunities and threats for the EU without the United Kingdom, which counterbalanced the influence of Germany and France in Europe.