The focus of this study explores the influence of the Church's mission perspective on the Congregatio Missionis (CM) mission perspective in Madagascar in 1648. The mission of the Church in the context of that time had a negative meaning. The motivation for the proclamation of faith overlapped with the political motivation of Western imperialism. The process of colonization of countries in the Asian, American and African continents is difficult to separate from the influence of Christianity in them. The mission of the Church coupled with the practice of colonization and Western imperialism influenced the perspective of mission and spirituality of the congregation at that time. Every congregation has a constitution and basis for its ministry. This foundation has a distinctive charismatic character. The signs of the times and the pressing needs of the Church affect the spirituality and charismatic character of a congregation. This study wants to examine the extent to which the missionary state of the Church at that time affected the charism of the Congregatio Missionis (CM). The method used in this study is the qualitative-comparative method. The letter of St. Vincent to the Congregatio Missionis missionaries in Madagascar in 1648 is analyzed and assessed in the perspective of the mission of the Church in the XVII century. The study found that the mission perspective of the XVII century emphasized the spread of the faith, the conversion of unbelievers, the expansion of the reign of God, and the establishment of new churches. In particular, the study found that the mission perspectives of the XVII century Church were similar to those of the Congregatio Missionis (CM) in Madagascar based on St. Vincent's letter to his missionaries. If traced further, the seeds of the Church's current mission perspective and the principle of inculturation in the understanding of mission according to St. Vincent are also found.