This case study describes the evolution of a 45-year-old patient who presented to the hospital with a severe inferior respiratory tract infection. The interpretation of the electrocardiogram led to a reconsideration of the medical history and the identification of anginal pain, resulting in referral to the cardiology department. The investigations carried out (biochemical tests, stress test, and coronary angiography) established the diagnosis of angina with non-obstructive coronary arteries (ANOCA). The uniqueness of the case lies in the association of this diagnosis with a combination of traditional cardiovascular risk factors (hypertension, dyslipidemia) and non-traditional factors (chronic inflammation, psychosocial stress). The average duration for establishing the diagnosis of ANOCA remains prolonged, contributing to the decrease in patient’s quality of life. This case emphasizes the need for more efficient educational, diagnostic, and therapeutic strategies. It is essential to increase public awareness regarding the importance of addressing subtle symptoms that can be mistaken for the effects of aging and to reduce diagnostic delays in order to improve cardiovascular prognosis