In Oncoguía del manejo del dolor en cáncer 2023, we present the cancer pain epidemiology, its clinical presentations, and the methodology for its diagnostic approach. We have considered the extension studies (when necessary) to design an individualized therapeutic scheme, besides the different patient domains (organic, comorbidities, beliefs, and expectations) to implement pharmacological and non-pharmacological measures. Likewise, we added other health areas that may optimize the treatment for pain in this group of patients.