Background: The recent studies concerning antiviral therapy in HBV-related cirrhosis showed the promising results. This study aimed to assess /The aim of this study was to assess the quantity of HBeAg, HBV DNA and identify some related factors in patients with HBV-induced cirrhosis. Patients and methods: 60 patients with HBsAg positive-cirrhosis were enrolled in the study. HBeAg was done by ELISA and HBV DNA was quantified by Realtime PCR assay with kit from Viet A company. Results: The rate of HBeAg positive patients with HBV cirrhosis was: 58.33%; the rate of cirrhosic patients with HBV DNA > 104 copies/ml was 68%. There was a statistically significant relationship between high levels of serum HBV DNA and somes signs of cirrhosis such as grade 3 -ascites, hypoalbuminemia, hyperbilirubinemia, prolonged prothrombin time and thrombocytopenia. Conclusion: The markers of viral replication were still common in patients with HBV cirrhosis, even decompensated cirrhosis.