The Coronavirus Nucleocapsid Is a Multifunctional Protein

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 07 Aug 2014 South Africa English Publisher:MDPI AGJournal:Viruses, volume 6, pages 2,991-3,018 (eissn: 1999-4915,

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Authors: Ruth McBride; Marjorie Van Zyl; Burtram Fielding;

doi: 10.3390/v6082991

pmid: 25105276

pmc: PMC4147684

handle: 10566/2241

The Coronavirus Nucleocapsid Is a Multifunctional Protein

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Abstract

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.

Country

South Africa

Related Organizations

University of the Western Cape
South Africa

Keywords

Nucleocapsid protein, intracellular localization, Coronavirus N, coronavirus N, Protein topology, Coronavirus assembly, coronavirus assembly, Review, Nucleocapsid Proteins, Virus Replication, Microbiology, QR1-502, Coronavirus, Protein Transport, Intracellular localization, Coronavirus Nucleocapsid Proteins, protein topology, nucleocapsid protein

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