Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
Copyright policy )Host Restriction of Lentiviruses and Viral Countermeasures: APOBEC3 and Vif
It is becoming increasingly clear that organisms have developed a variety of mechanisms to fight against viral infection. The viruses have developed means of counteracting these defences in various ways. The APOBEC3 proteins are a mammalian-specific family of nucleic acid cytidine deaminases that block retroviral infection. These inhibitors are counteracted by the Vif proteins encoded by most lentiviruses. In this paper, we will review the interaction of the lentiviral Vif proteins with the APOBEC3 proteins, with an emphasis on sheep APOBEC3 and maedi-visna virus (MVV) Vif.
- University of Iceland Iceland
Gene Products, vif, Sheep, host defence, Visna-maedi virus, Virulence Factors, Sheep Diseases, APOBEC3, Review, restriction factors, Microbiology, Vif, QR1-502, Cytosine Deaminase, small ruminant lentivirus, maedi-visna virus, Host-Pathogen Interactions, Animals
Gene Products, vif, Sheep, host defence, Visna-maedi virus, Virulence Factors, Sheep Diseases, APOBEC3, Review, restriction factors, Microbiology, Vif, QR1-502, Cytosine Deaminase, small ruminant lentivirus, maedi-visna virus, Host-Pathogen Interactions, Animals
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