This paper presents an analytical framework for the probability of spectrum hole utilization (PSHU) of a cognitive radio system with soft cooperative spectrum sensing (CSS) under a practical consideration of fixed frame structure. In practical systems, the length of a time-frame is generally fixed, where the time-frame consists of sensing, reporting, and transmission durations. Thus, increasing sensing and reporting time duration in cooperative spectrum sensing improves the probability of successful detection of the primary user’s (PU) presence or the absence but reduces transmission time duration, which results in a lower PSHU. A large reporting duration is required when more secondary users (SUs) report their sensed information to the fusion center (FC) and/or multiple bits are used by each SU in soft cooperative spectrum sensing. Thus, reporting time in terms of the number of SUs and reporting bits also have a similar effect on PSHU. Based on this interesting trade-off between PSHU and the sensing and reporting time duration, this paper analyzes the impact of an increasing number of SUs and reporting bits on PSHU.