This study analyzes the possibility of utilizing artificial neural networks (ANNs) to characterize the drying kinetics of linden leaf samples during infrared drying (IRD) at different temperatures (50, 60, and 70 °C) with sample thicknesses between 0.210 mm and 0.230 mm. The statistical parameters were constructed using several thin-layer models and ANN techniques. The coefficient of determination (R2) and root mean square error (RMSE) were utilized to evaluate the appropriateness of the models. The effective moisture diffusivity ranged from 4.13 × 10−12 m2/s to 5.89 × 10−12 m2/s, and the activation energy was 16.339 kJ/mol. The applied Page, Midilli et al., Henderson and Pabis, logarithmic, and Newton models could sufficiently describe the kinetics of linden leaf samples, with R2 values of >0.9900 and RMSE values of <0.0025. The ANN model displayed R2 and RMSE values of 0.9986 and 0.0210, respectively. In addition, the ANN model made significantly accurate predictions of the chemical properties of linden of total phenolic content (TPC), total flavonoid content (TFC), DPPH, and FRAP, with values of R2 of 0.9975, 0.9891, 0.9980, and 0.9854, respectively. The validation of the findings showed a high degree of agreement between the anticipated values generated using the ANN model and the experimental moisture ratio data. The results of this study suggested that ANNs could potentially be applied to characterize the drying process of linden leaves and make predictions of their chemical contents.