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Using Chitosan or Chitosan Derivatives in Cancer Therapy

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 13 Oct 2021 English Publisher:MDPI AGJournal:Polysaccharides, volume 2, pages 795-816 (eissn: 2673-4176,

Authors: Md Salman Shakil; Kazi Mustafa Mahmud; Mohammad Sayem; Mahruba Sultana Niloy; Sajal Kumar Halder; Md. Sakib Hossen; Md. Forhad Uddin; +1 Authors

doi: 10.3390/polysaccharides2040048

Using Chitosan or Chitosan Derivatives in Cancer Therapy

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Abstract

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

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Keywords

anticancer activities, chitosan derivatives, immunotherapy, QD415-436, chitosan, gene and drug delivery, Biochemistry

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	64
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 1%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 1%