The emerging areas of polymer nanocomposites, as some are already in use in industrial applications and daily commodities, have the potential of offering new technologies with all manner of prominent capabilities. The incorporation of nanomaterials into polymeric matrix provides significant improvements, such as higher mechanical, thermal or electrical properties. In these materials, interface/interphase of components play a crucial role bringing additional features on the resulting nanocomposites. Among the various preparation strategies of such materials, an appealing strategy relies on the use of click chemistry concept as a multi-purpose toolbox for both fabrication and modulation of the material characteristics. This review aims to deliver new insights to the researchers of the field by noticing effective click chemistry-based methodologies on the preparation of polymer nanocomposites and their key applications such as optic, biomedical, coatings and sensor.