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Borate Minerals and RNA Stability

Authors: Cristina Cossetti; Claudia Crestini; Raffaele Saladino; DI MAURO, Ernesto;

Borate Minerals and RNA Stability

Abstract

The abiotic origin of genetic polymers faces two major problems: a prebiotically plausible polymerization mechanism and the maintenance of their polymerized state outside a cellular environment. The stabilizing action of borate on ribose having been reported, we have explored the possibility that borate minerals stabilize RNA. We observe that borate itself does not stabilize RNA. The analysis of a large panel of minerals tested in various physical-chemical conditions shows that in general no protection on RNA backbone is exerted, with the interesting exception of ludwigite (Mg2Fe3+BO5). Stability is a fundamental property of nucleic polymers and borate is an abundant component of the planet, hence the prebiotic interest of this analysis.

Country
Italy
Keywords

Division of Chemistry, borate minerals, Origin of genetic polymers; RNA stability; RNA hydrolysis; Borate minerals, Settore CHIM/06 - CHIMICA ORGANICA, RNA stability, Settore CHIM/03 - CHIMICA GENERALE E INORGANICA, origin of genetic polymer, Borate minerals; Origin of genetic polymers; RNA hydrolysis; RNA stability; Chemistry (all); Polymers and Plastics, origin of genetic polymers; RNA stability; RNA hydrolysis; borate minerals, Origin of genetic polymers, Borate minerals, National Science Foundation, RNA hydrolysi, Directorate for Mathematical & Physical Sciences, Origin of genetic polymer, rna hydrolysis; origin of genetic polymers; borate minerals; rna stability, NSF, RNA hydrolysis

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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