To develop the full application potential of composite materials, research on the post-buckling behavior of composite stiffened panels is of great significance. In this paper, the impact and compression after impact (CAI) behaviors of four different types of composite stiffened panels were studied by numerical simulation and experimental methods. The low-velocity impact damage simulated dynamically was introduced as the initial state in the compression simulation, and a two-dimensional shell model with Hashin failure criteria and stiffness degradation was adopted to estimate the failure load of composite stiffened panels under impact and CAI. The error between simulation results and test results was less than 10%, showing that the method used in this study achieved considerable accuracy in experimental results. Analysis of the impact test results revealed that the extent of damage is related to many factors, including the cross-sectional size of stiffeners, the spacing of stiffeners, and the material and thickness of the skin. In addition, the influence of fatigue damage on residual strength after impact was also studied experimentally, with results showing that the buckling and failure loads decreased by about 5% under 106 flight fatigue loads. However, there were obvious fluctuations in the load-displacement curves, which may have been caused by debonding between the stiffeners and the skin. Experimental results and the simulation matrix show that the post-buckling ratio increased with the increase of the stiffness ratio, then was stable after 2.0. Furthermore, the thinner the skin, the greater the post-buckling ratio. The experimental and simulation results provide an important reference for the structural design and failure-mechanism analysis of composite stiffened panels.