In this review, the application of deep eutectic solvents (DESs) as starch solvents, plasticizers and for other treatment has been described. Starch, as one of the most abundant biopolymers, is considered for forming new biodegradable materials. This new approach, referring to applying deep eutectic solvents for dissolving starch, its plasticization and other modifications, was presented. A DES could be a good alternative for common starch plasticizers (e.g., glycerol, urea) as well as recently considered ionic liquids. The high variety of DES component combinations makes it possible to obtain materials with the properties specific for given applications.