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Pharmaceuticals
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Pharmaceuticals
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Claim

The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 08 Apr 2013 English Publisher:MDPI AGJournal:Pharmaceuticals, volume 6, pages 500-509 (eissn: 1424-8247, Copyright policy )
Authors: Huayun Deng; Ye Fang;

doi: 10.3390/ph6040500

pmid: 24276120

pmc: PMC3816702

The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists

Abstract

Nearly 1% of all clinically used drugs are catecholics, a family of catechol-containing compounds. Using label-free dynamic mass redistribution and Tango β-arrestin translocation assays, we show that several catecholics, including benserazide, catechol, 3-methoxycatechol, pyrogallol, (+)-taxifolin and fenoldopam, display agonistic activity against GPR35.

Related Organizations
Keywords

RS1-441, Pharmacy and materia medica, R, Medicine, benserazide, catechol, pyrogallol, GPR35, Article

  • BIP!
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    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 14
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
14
Average
Average
Top 10%
Green
gold