Host Genetic Factors in Q Fever Susceptibility

descriptionPublicationkeyboard_double_arrow_right Article 18 Apr 2025 English Publisher:MDPI AGJournal:Pathogens, volume 14, page 394 (eissn: 2076-0817,

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Authors: José-María Robaina Bordón; José-Luis Pérez-Arellano; Olga Montes-Ares; Alberto Torio-Ruiz; Michele Hernández-Cabrera; Elena Pisos-Álamo; Cristina Carranza-Rodríguez;

doi: 10.3390/pathogens14040394

pmid: 40333225

pmc: PMC12030616

Host Genetic Factors in Q Fever Susceptibility

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Abstract

Several indirect findings suggest that host-related factors influence susceptibility to Coxiella burnetii infection. We decided to explore the influence of genetic factors related to both innate and adaptive immunity in acute Q fever susceptibility. TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) polymorphisms, along with HLA-DRB1 alleles, were analyzed for 38 patients with acute Q fever, 38 matched controls, and 121 blood donors. No significant associations were found for TLR polymorphisms. However, HLA-DRB1*04 was more frequent in patients. HLA-DRB1 variants may play a role in Q fever susceptibility, supporting the need for further investigation into their potential implications for vaccination and risk assessment.

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Keywords

Male, Adult, Polymorphism, Genetic, host genetic factors, Brief Report, Immune-Response Genes, R, Middle Aged, Toll-Like Receptor 2, <i>Coxiella burnetii</i>, Toll-Like Receptor 4, Host Genetic Factors, 3207 Patología, Coxiella burnetii, Coxiella-Burnetii, Medicine, Humans, Genetic Predisposition to Disease, Female, <Italic>Coxiella Burnetii</Italic>, Polymorphisms, Q Fever, 32 Ciencias médicas, Q fever, HLA-DRB1 Chains

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