Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development

descriptionPublicationkeyboard_double_arrow_right Article , Conference object 13 Jan 2023 English Publisher:MDPI AGJournal:Pathogens, volume 12, page 138 (eissn: 2076-0817,

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Authors: Christin Schmidt; Barbara S. Schnierle;

doi: 10.3390/pathogens12010138

pmid: 36678486

pmc: PMC9863218

Self-Amplifying RNA Vaccine Candidates: Alternative Platforms for mRNA Vaccine Development

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Abstract

The present use of mRNA vaccines against COVID-19 has shown for the first time the potential of mRNA vaccines for infectious diseases. Here we will summarize the current knowledge about improved mRNA vaccines, i.e., the self-amplifying mRNA (saRNA) vaccines. This approach may enhance antigen expression by amplification of the antigen-encoding RNA. RNA design, RNA delivery, and the innate immune responses induced by RNA will be reviewed.

Related Organizations

Paul Ehrlich Institut
Germany

Keywords

self-amplifying RNA, vaccine, mRNA, R, alphavirus, Medicine, Review, innate immunity

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