Alterations in One-Carbon Metabolism in Celiac Disease
Copyright policy )Alterations in One-Carbon Metabolism in Celiac Disease
Celiac disease (CD) is an autoimmune enteropathy associated with alterations of metabolism. Metabolomics studies, although limited, showed changes in choline, choline-derived lipids, and methionine concentrations, which could be ascribed to alterations in one-carbon metabolism. To date, no targeted metabolomics analysis investigating differences in the plasma choline/methionine metabolome of CD subjects are reported. This work is a targeted metabolomic study that analyzes 37 metabolites of the one-carbon metabolism in 17 children with CD, treated with a gluten-free diet and 17 healthy control siblings, in order to establish the potential defects in this metabolic network. Our results demonstrate the persistence of defects in the transsulfuration pathway of CD subjects, despite dietary treatment, while choline metabolism, methionine cycle, and folate cycle seem to be reversed and preserved to healthy levels. These findings describe for the first time, a metabolic defect in one-carbon metabolism which could have profound implications in the physiopathology and treatment of CD.
Male, Folate cycle, Adolescent, Metionina, methionine savage pathway, Transsulfuration pathway, Article, Choline, Diet, Gluten-Free, Folic Acid, Methionine, choline, Methionine cycle, Celiac disease, Humans, Metabolomics, transsulfuration pathway, Child, mass spectrometry, Metabolismo, amino acids, Methionine savage pathway, Mass spectrometry, Metabolómica, folate cycle, Dieta sin gluten, Carbon, Celiac Disease, Cross-Sectional Studies, methionine cycle, Child, Preschool, Lípidos, Metabolome, Amino acids, Female, Ácido fólico, celiac disease, Metabolic Networks and Pathways
Male, Folate cycle, Adolescent, Metionina, methionine savage pathway, Transsulfuration pathway, Article, Choline, Diet, Gluten-Free, Folic Acid, Methionine, choline, Methionine cycle, Celiac disease, Humans, Metabolomics, transsulfuration pathway, Child, mass spectrometry, Metabolismo, amino acids, Methionine savage pathway, Mass spectrometry, Metabolómica, folate cycle, Dieta sin gluten, Carbon, Celiac Disease, Cross-Sectional Studies, methionine cycle, Child, Preschool, Lípidos, Metabolome, Amino acids, Female, Ácido fólico, celiac disease, Metabolic Networks and Pathways
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