Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
Copyright policy )Recent Advances in Synthetic Drugs and Natural Actives Interacting with OAT3
Organic anion transporter 3 (OAT3) is predominantly expressed in the kidney and plays a vital role in drug clearance. Consequently, co-ingestion of two OAT3 substrates may alter the pharmacokinetics of the substrate. This review summarizes drug–drug interactions (DDIs) and herbal–drug interactions (HDIs) mediated by OAT3, and inhibitors of OAT3 in natural active compounds in the past decade. This provides a valuable reference for the combined use of substrate drugs/herbs for OAT3 in clinical practice in the future and for the screening of OAT3 inhibitors to avoid harmful interactions.
- Beijing Technology and Business University China (People's Republic of)
Synthetic Drugs, Herb-Drug Interactions, Organic chemistry, Review, Organic Anion Transporters, Sodium-Independent, organic anion transporter 3, herb–drug interactions, Kidney, natural active compounds, QD241-441, Organic Anion Transport Protein 1, HEK293 Cells, inhibitors, drug–drug interactions, Humans
Synthetic Drugs, Herb-Drug Interactions, Organic chemistry, Review, Organic Anion Transporters, Sodium-Independent, organic anion transporter 3, herb–drug interactions, Kidney, natural active compounds, QD241-441, Organic Anion Transport Protein 1, HEK293 Cells, inhibitors, drug–drug interactions, Humans
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