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Imaging Sequences for Hyperpolarized Solids

Authors: Xudong Lv; Jeffrey Walton; Emanuel Druga; Raffi Nazaryan; Haiyan Mao; Alexander Pines; Ashok Ajoy; +1 Authors

Imaging Sequences for Hyperpolarized Solids

Abstract

Hyperpolarization is one of the approaches to enhance Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) signal by increasing the population difference between the nuclear spin states. Imaging hyperpolarized solids opens up extensive possibilities, yet is challenging to perform. The highly populated state is normally not replenishable to the initial polarization level by spin-lattice relaxation, which regular MRI sequences rely on. This makes it necessary to carefully “budget” the polarization to optimize the image quality. In this paper, we present a theoretical framework to address such challenge under the assumption of either variable flip angles or a constant flip angle. In addition, we analyze the gradient arrangement to perform fast imaging to overcome intrinsic short decoherence in solids. Hyperpolarized diamonds imaging is demonstrated as a prototypical platform to test the theory.

Country
United States
Keywords

Magnetic Resonance Spectroscopy, Image Processing, 610, Organic chemistry, Signal-To-Noise Ratio, 530, Phantoms, Article, Imaging, Medicinal and Biomolecular Chemistry, Magnetics, Computer-Assisted, QD241-441, Theoretical and Computational Chemistry, Medicinal and biomolecular chemistry, Image Processing, Computer-Assisted, magnetic resonance imaging, hyperpolarization, Carbon Isotopes, Fourier Analysis, Phantoms, Imaging, Organic Chemistry, Equipment Design, Magnetic Resonance Imaging, 4.1 Discovery and preclinical testing of markers and technologies, flip angle, Chemical Sciences, Calibration, Biomedical Imaging, Diamond, Algorithms

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    popularity
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    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
1
Average
Average
Average
Green
gold