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Conformation of G-quadruplex Controlled by Click Reaction

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 22 Sep 2020 English Publisher:MDPI AGJournal:Molecules, volume 25, page 4,339 (eissn: 1420-3049,

Authors: Chao-Da Xiao; Zhi-Yong He; Chuan-Xin Guo; Xiang-Chun Shen; Yan Xu;

doi: 10.3390/molecules25184339

pmid: 32971833

pmc: PMC7570587

Conformation of G-quadruplex Controlled by Click Reaction

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Abstract

G-quadruplexes are non-canonical four stranded secondary structures possessing great biological importance. Controlling G-quadruplex conformation for further regulating biological processes is both exciting and challenging. In this study, we described a method for regulating G-quadruplex conformation by click chemistry for the first time. 8-ethynyl-2′-deoxyguanosine was synthesized and incorporated into a 12-nt telomere DNA sequence. Such a sequence, at first, formed mixed parallel/anti-parallel G-quadruplexes, while it changed to anti-parallel after reaction with azidobenzene. Meanwhile, the click reaction can give the sequence intense fluorescence.

Related Organizations

University Town of Shenzhen
China (People's Republic of)
University of Miyazaki
Japan
Xuzhou Medical University
China (People's Republic of)
Guiyang Medical University
China (People's Republic of)

Keywords

G-quadruplex, Organic chemistry, Deoxyguanosine, NMR, Article, circular dichroism, G-Quadruplexes, QD241-441, conformation change, Click Chemistry, click reaction

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