N-oxide alkaloids from Crinum amabile (Amaryllidaceae)

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 26 May 2018Embargo end date: 01 Jan 2018 Switzerland, Spain, Spain English Publisher:MDPI AGJournal:Molecules, volume 23, page 1,277 (eissn: 1420-3049,

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Authors: Luciana R. Tallini; Laura Torras-Claveria; Warley de Souza Borges; Marcel Kaiser; Francesc Viladomat; José Angelo S. Zuanazzi; Jaume Bastida;

doi: 10.3390/molecules23061277 , 10.5451/unibas-ep65032

pmid: 29861456

pmc: PMC6099558

handle: 2445/156462

N-oxide alkaloids from Crinum amabile (Amaryllidaceae)

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Abstract

Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from Crinum amabile by GC-MS and two new structures (augustine N-oxide and buphanisine N-oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from C. amabile gave better results than the reference drugs, so it was possible to conclude that the N-oxide group does not increase their therapeutic potential.

Countries

Switzerland, Spain, Spain

Related Organizations

Faculty of Pharmacy
Universidade Federal do Espírito Santo
Brazil
University of Barcelona
Spain
Universitat de Barcelona
University of Basel
Switzerland

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Keywords

Magnetic Resonance Spectroscopy, Phytochemicals, Antiprotozoal Agents, Organic chemistry, buphanisine N-oxide, buphanisine N-oxide, Article, Gas Chromatography-Mass Spectrometry, Inhibitory Concentration 50, QD241-441, Alkaloids, Crinum amabile, Natural products, Molecular Structure, augustine N-oxide, Amaril·lidàcies, Plant Extracts, Amaryllidaceae, biological activities, Drugs, Oxides, augustine N-oxide, Crinum amabile, Crinum, Amaryllidaceae Alkaloids, Productes naturals, Cholinesterase Inhibitors, Medicaments

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