Metabolites Produced by an Endophytic Phomopsis sp. and Their Anti-TMV Activity

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 27 Nov 2017 English Publisher:MDPI AGJournal:Molecules, volume 22, page 2,073 (eissn: 1420-3049,

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Authors: Qing-Wei Tan; Pei-Hua Fang; Jian-Cheng Ni; Fangluan Gao; Qi-Jian Chen;

doi: 10.3390/molecules22122073

pmid: 29186928

pmc: PMC6149851

Metabolites Produced by an Endophytic Phomopsis sp. and Their Anti-TMV Activity

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Abstract

The fermentation and isolation of metabolites produced by an endophytic fungus, which was identified as Phomopsis sp. FJBR-11, based on phylogenetic analysis, led to the identification of six compounds, including dothiorelones A–C, and H, and cytosporones C and U. Among these compounds, cytosporone U exhibited potent inhibitory activity against Tobacco mosaic virus (TMV). Moreover, the crude and a purified exopolysaccharide were proved to possess strong inhibitory effects against the virus infection.

Related Organizations

Fujian Agriculture and Forestry University
China (People's Republic of)

Keywords

Polysaccharides, Bacterial, Phomopsis, Organic chemistry, Secondary Metabolism, Antiviral Agents, Article, Tobacco Mosaic Virus, Structure-Activity Relationship, QD241-441, cytosporone, Ascomycota, dothiorelone, Drug Discovery, Fermentation, Tobacco mosaic virus, Humans, <i>Phomopsis</i>; dothiorelone; cytosporone; <i>Tobacco mosaic virus</i>, Phylogeny

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