Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines
Copyright policy )Organocatalytic Access to Enantioenriched Spirooxindole-Based 4-Methyleneazetidines
This work describes the synthesis of enantioenriched spiro compounds, incorporating the azetidine and the oxindole motifs. The preparation relies on a formal [2 + 2] annulation reaction of isatin-derived N-tert-butylsulfonyl ketimines with allenoates. The asymmetric induction is secured by an organocatalytic strategy, exploiting a bifunctional cinchona-type β-isocupridine-based catalyst. Some post-transformation products, including unexpected spiropyrroline and 3,3-disubstituted oxindole derivatives, are also presented.
- University of Milan Italy
- Department of Chemistry Austria
- University of Milan Italy
- Vrije Universiteit Amsterdam Netherlands
- Department of Chemistry Switzerland
Isatin, Cinchona-based catalysts, Azetidines; Cinchona-based catalysts; Organocatalysis; Spirooxindoles; organic chemistry, Organocatalysis, spirooxindoles, spirooxindoles; organocatalysis; azetidines; cinchona-based catalysts, Organic chemistry, Spirooxindoles, azetidines, Article, Catalysis, QD241-441, cinchona-based catalysts, Models, Chemical, Nitriles, Azetidines, organocatalysis, Spiro Compounds, Imines, SDG 6 - Clean Water and Sanitation
Isatin, Cinchona-based catalysts, Azetidines; Cinchona-based catalysts; Organocatalysis; Spirooxindoles; organic chemistry, Organocatalysis, spirooxindoles, spirooxindoles; organocatalysis; azetidines; cinchona-based catalysts, Organic chemistry, Spirooxindoles, azetidines, Article, Catalysis, QD241-441, cinchona-based catalysts, Models, Chemical, Nitriles, Azetidines, organocatalysis, Spiro Compounds, Imines, SDG 6 - Clean Water and Sanitation
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).17 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!