Capsaicin, Nociception and Pain
Copyright policy )Capsaicin, Nociception and Pain
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved in somatic and visceral peripheral inflammation, in the modulation of nociceptive inputs to spinal cord and brain stem centers, as well as the integration of diverse painful stimuli. In this review, we first describe the chemical and pharmacological properties of capsaicin and its derivatives in relation to their analgesic properties. We then consider the biochemical and functional characteristics of TRPV1, focusing on its distribution and biological effects within the somatosensory and viscerosensory nociceptive systems. Finally, we discuss the use of capsaicin as an agonist of TRPV1 to model acute inflammation in slices and other ex vivo preparations.
- Umeå University Sweden
- University of Turin Italy
Nociception, Organic chemistry, Pain, TRPV Cation Channels, Review, TRPV1 receptor, capsaicin, sensitization, Pharmaceutical Sciences, QD241-441, resinferatoxin, Humans, Analgesia; Capsaicin; Nociception; Resinferatoxin; Sensitization; Somatic pain; TRPV1 receptor; Vanilloids; Visceral pain; Medicine (all); Organic Chemistry, nociception, Inflammation, Analgesics, analgesia, Farmaceutiska vetenskaper, Spinal Cord, visceral pain, somatic pain, Capsaicin, vanilloids, sinferatoxin
Nociception, Organic chemistry, Pain, TRPV Cation Channels, Review, TRPV1 receptor, capsaicin, sensitization, Pharmaceutical Sciences, QD241-441, resinferatoxin, Humans, Analgesia; Capsaicin; Nociception; Resinferatoxin; Sensitization; Somatic pain; TRPV1 receptor; Vanilloids; Visceral pain; Medicine (all); Organic Chemistry, nociception, Inflammation, Analgesics, analgesia, Farmaceutiska vetenskaper, Spinal Cord, visceral pain, somatic pain, Capsaicin, vanilloids, sinferatoxin
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