Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
Copyright policy )Three New Triterpene Esters from Pumpkin (Cucurbita maxima) Seeds
Three new multiflorane-type triterpene esters, i.e. 7α-hydroxymultiflor-8-ene-3α,29-diol 3-acetate-29-benzoate (1), 7α-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (2), and 7β-methoxymultiflor-8-ene-3α,29-diol 3,29-dibenzoate (3), were isolated from seeds of Cucurbita maxima, along with the known compound, multiflora-7,9(11)-diene-3α,29-diol 3,29-dibenzoate (4). Compound 1 exhibited melanogenesis inhibitory activities comparable with those of arbutin. In cytotoxicity assays, compounds 1 and 3 exhibited weak cytotoxicity, with IC50 values of 34.5–93.7 μM against HL-60 and P388 cells.
Melanins, Molecular Structure, Cucurbita maxima, Cell Survival, Arbutin, Organic chemistry, Esters, Antineoplastic Agents, Phytogenic, melanogenesis inhibitory activity, Article, Triterpenes, Inhibitory Concentration 50, QD241-441, Cucurbita, <i>Cucurbita maxima</i>; multiflorane-type triterpene; melanogenesis inhibitory activity; cytotoxic activity, Cell Line, Tumor, multiflorane-type triterpene, Seeds, Humans, cytotoxic activity
Melanins, Molecular Structure, Cucurbita maxima, Cell Survival, Arbutin, Organic chemistry, Esters, Antineoplastic Agents, Phytogenic, melanogenesis inhibitory activity, Article, Triterpenes, Inhibitory Concentration 50, QD241-441, Cucurbita, <i>Cucurbita maxima</i>; multiflorane-type triterpene; melanogenesis inhibitory activity; cytotoxic activity, Cell Line, Tumor, multiflorane-type triterpene, Seeds, Humans, cytotoxic activity
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