Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
Copyright policy )Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilus
Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-(L-Leu-L-Pro) (1), 3-hydroxyacetylindole (2), N-acetyl-b-oxotryptamine (3), cyclo-(L-Phe-L-Pro) (4), and 3-formylindole (5). The structures of compounds 1−5 were established by spectroscopic analyses, including HRESITOF-MS and NMR (1H, 13C, HSQC, HMBC and COSY). Compounds 2, 3 and 5 caused the inhibition on the growth of Trypanosoma cruzi (T. cruzi), with IC50 values of 20.6, 19.4 and 26.9 μM, respectively, with moderate cytotoxicity against Vero cells. Compounds 1−5 were found to be inactive when tested against Plasmodium falciparum and Leishmania donovani, therefore showing selectivity against T. cruzi parasites.
- Smithsonian Tropical Research Institute United States
- Smithsonian Tropical Research Institute Panama
- CINVESTAV Mexico
- City of Knowledge Panama
- SMITHSONIAN INSTITUTION
Chagas disease, <em>Trypanosoma cruzi</em>, Trypanosoma cruzi, Plasmodium falciparum, Organic chemistry, Bacillus, Anthozoa, Trypanocidal Agents, Article, <em>Bacillus</em> <em>pumilus</em>, Cell Line, QD241-441, Alkaloids, Parasitic Sensitivity Tests, indole alkaloids, Chlorocebus aethiops, Animals, Humans, Vero Cells, Bacillus pumilus, Leishmania donovani
Chagas disease, <em>Trypanosoma cruzi</em>, Trypanosoma cruzi, Plasmodium falciparum, Organic chemistry, Bacillus, Anthozoa, Trypanocidal Agents, Article, <em>Bacillus</em> <em>pumilus</em>, Cell Line, QD241-441, Alkaloids, Parasitic Sensitivity Tests, indole alkaloids, Chlorocebus aethiops, Animals, Humans, Vero Cells, Bacillus pumilus, Leishmania donovani
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